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PRODID:-//Virginia Tech//VT Calendar//EN
BEGIN:VEVENT
DTSTAMP:20110223T170000Z
UID:1297265131926@events.msu.edu
CATEGORIES:Conferences / Seminars / Lectures
DTSTART:20110223T170000Z
DTEND:20110223T180000Z
SUMMARY:Centrally Mediated Enhanced Sympathetic Outflow in Heart Failure
DESCRIPTION:
 Patients with heart failure (HF) and all animal 
 models of HF exhibit an increased sympathetic 
 neural activation, which increases the risk 
 of mortality during HF. The central mechanisms 
 that underlie these abnormalities are poorly 
 understood. We have previously observed that 
 central nitric oxide (NO) mechanisms within 
 the PVN that dictate sympathetic outflow are 
 altered in HF. Subsequently, we determined 
 that NO via a γ-amino butyric acid (GABA) 
 mechanism, representing an inhibitory mechanism, 
 is augmented in HF. Recently we uncovered 
 enhanced excitatory mechanisms involving 
 glutamatergic and angiotensinergic (also influenced 
 by NO) within the PVN in HF. These data 
 taken together suggest that altered inhibitory 
 mechanisms involving NO and GABA and excitatory 
 mechanisms involving glutamatergic and 
 angiotensinergic pathways within the PVN (with 
 interactions between the two mechanisms involving 
 NO) may be involved in this sympatho-excitation. 
 We have subsequently shown that; 
 first, restoring the reduced levels of nNOS (using 
 gene transfer) restores the blunted inhibitory 
 mechanisms (NO/GABA) and ameliorates 
 increased excitatory (glutamatergic) systems 
 in the PVN; second, exercise training restores 
 the levels of nNOS within the PVN and restores 
 the enhanced sympathoexcitation observed 
 in chronic heart failure. Understanding the role 
 of central mechanisms, in the increased sympathetic 
 neural drive will enhance our ability 
 to treat the HF condition and its cardiovascular 
 complications.\n\n
 Price: free\n
 Sponsor: Dept of Pharmacology & Toxicology\n
 Sponsor's Homepage: http://phmtox.msu.edu\n
 Contact name: Diane Hummel\n
 Contact phone: 353-9616\n
 Contact email: phm@msu.edu\n
 for more info visit the web at:\n 
 http://phmtox.msu.edu/events/pdf/PATEL--Flyer.pdf\n
LOCATION:B448-49 Life Sciences Building
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