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PRODID:-//Virginia Tech//VT Calendar//EN
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DTSTAMP:20111005T160000Z
UID:1316625125936@events.msu.edu
CATEGORIES:Conferences / Seminars / Lectures
DTSTART:20111005T160000Z
DTEND:20111005T170000Z
SUMMARY:SERIOUS BACTERIAL INFECTION AND THE HEMATOPOIETIC STEM CELL RESPONSE
DESCRIPTION:
 In response to serious bacterial infection, the 
 bone marrow hematopoietic activity shifts toward 
 granulocyte production, which is critical 
 for host defense. At the present time, knowledge 
 about the commitment of hematopoietic 
 precursor cells including hematopoietic stem 
 cells and progenitors in this response remains 
 scant. Our recent studies have shown that bacteremia 
 causes a marked increase in the number 
 of hematopoietic stem cells bearing the lineage 
 (lin)-c-kit+Sca-1+ (LKS) surface markers 
 in the bone marrow of mice. This dramatic 
 expansion of the LKS cell pool results from both 
 increased mitosis of these cells and inversion 
 from lin-c-kit+Sca-1- cell phenotype. TLR4-JNK-AP1 
 signaling plays a major role in mediating 
 phenotypic inversion of lin-c-kit+Sca-1- 
 cells. Cells in the expanded LKS cell pool 
 are transcriptionally reprogrammed for enhancing 
 their commitment to myeloid lineage development. 
 These primitive precursors contain 
 an increased number of colony-forming unit-granulocyte/macrophage 
 (CFU-GM). Mobilization 
 of LKS cells into the circulation is significantly 
 increased during bacteremia. Kidney capsule 
 implantation test shows that LKS cells generated 
 from inversion of lin-c-kit+Sca-1- cells 
 following LPS stimulation possess a strong 
 activity of extramedullary granulopoiesis. 
 These results demonstrate that the lin-c-kit+Sca-1+ 
 cell population in the bone marrow constitutes 
 a key component of the host defense 
 response to bacteremia. Functional modifications 
 of these primitive hematopoietic precursors 
 are critical for enhancing granulocyte production 
 following bacterial infection.\n\n
 Price: free\n
 Sponsor: Administration\n
 Sponsor's Homepage: http://phmtox.msu.edu\n
 Contact name: Diane Hummel\n
 Contact phone: (517) 353-9616\n
 Contact email: phm@msu.edu\n
 for more info visit the web at:\n 
 http://phmtox.msu.edu/events/pdf/ZHANG%20P--Flyer.pdf\n
LOCATION:B448-449 Life Sciences Building
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