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DTSTAMP:20120328T170000Z
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CATEGORIES:Conferences / Seminars / Lectures
DTSTART:20120328T170000Z
DTEND:20120328T180000Z
SUMMARY:THE ROLE OF NOVEL GUT-BONE SIGNALING IN OSTEOPOROSIS
DESCRIPTION:
 HOST: Anne Dorrance\n
 It is estimated that by 2020 
 more than 61 million men and women will have 
 osteoporosis. In fact, one in three women 
 over the age of 50 will experience an osteoporosis 
 related fracture in their lifetime. Along 
 with its associated increase in fracture 
 risk, bone loss may have negative effects on 
 metabolism and insulin secretion. Despite all 
 the anti-resorptive treatments on the market, 
 the number of osteoporotic patients is on the 
 rise in the U.S. and worldwide. Bone loss 
 can be caused by a variety of factors including 
 aging, menopause, and diseases such as those 
 examined in my laboratory: type 1 diabetes 
 and inflammatory bowel disease. Diagnosis of 
 T1D is increasing in children and adults. While 
 medical advances are extending patient lifespan, 
 maintaining euglycemia remains difficult, 
 even under therapeutic vigilance. Thus, 
 more T1D patients are suffering from complications, 
 including bone loss and its associated 
 increased fracture risk. We demonstrate that 
 T1D suppresses bone formation and strength while 
 altering bone marrow cell populations and 
 increasing marrow adiposity. We have incorporated 
 co-culture models, genetically modified 
 mouse models and human studies to identify 
 potential mechanisms/therapeutic targets. Similarly, 
 we have used the same approaches to examine 
 mechanisms of inflammatory bowel disease, 
 which led us to identify the gut as a potential 
 mediator of bone loss. We are now focusing 
 on the role of the gut environment as a 
 signal regulating bone loss in type 1 diabetes 
 as well as in estrogen deficiency (as is associated 
 with menopause). We have identified 
 significant gut changes that relate to bone health. 
 Taken together, our studies are moving 
 toward identifying basic signaling mechanisms 
 relating the GI tract to bone health.\n
 \n\n
 Price: free\n
 Sponsor: Administration\n
 Sponsor's Homepage: http://events.msu.edu/deptpharmacology/\n
 Contact name: Diane Hummel\n
 Contact email: phm@msu.edu\n
LOCATION:110 Radiology Bldg (Auditorium)
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