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PRODID:-//Virginia Tech//VT Calendar//EN
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DTSTAMP:20120411T160000Z
UID:1333645830249@events.msu.edu
CATEGORIES:Conferences / Seminars / Lectures
DTSTART:20120411T160000Z
DTEND:20120411T170000Z
SUMMARY:The Role of Hypoxia in Gastrointestinal Homeostasis
DESCRIPTION:
 YATRIK SHAH, PhD\n
 Assistant Professor\n
 Molecular 
 & Integrative Physiology\n
 University of Michigan\n
 Ann 
 Arbor, MI\n
 \n
 HOST: Bryan Copple\n
 \n
 Two billion years of evolution in an oxygen 
 environment has determined that oxygen occupies 
 a\n
 central feature of our biology. Cellular 
 oxygen is an important systemic signal that 
 modulates\n
 metabolic activities and disease 
 in the liver and intestine. Low cellular oxygen 
 also referred to as\n
 hypoxia is observed 
 in several gastrointestinal diseases such as 
 non-alcoholic and alcoholic fatty\n
 liver disease, 
 inflammatory bowel disease and liver and 
 colon cancers. Regulation of hypoxiamediated\n
 genes 
 is dependent on the nuclear transcription 
 factor, hypoxia inducible factor (HIF).\n
 HIF 
 signaling is critical in the adaptive response 
 to low oxygen levels by activating genes 
 involved\n
 in metabolism, angiogenesis, cell 
 survival and iron metabolism. Using the latest 
 in mouse\n
 transgenic technology we have developed 
 novel animal models to study accurately 
 the role of\n
 oxygen sensitive transcription 
 factors in the liver and intestine. The major 
 goal of our research\n
 program is to determine 
 the molecular mechanisms by which oxygen 
 sensing transcription factors\n
 regulate gastrointestinal 
 homeostasis, inflammation and cancer.\n\n
 Price: free\n
 Sponsor: Administration\n
 Sponsor's Homepage: http://events.msu.edu/deptpharmacology/\n
 Contact name: Diane Hummel\n
 Contact phone: 517-884-3553\n
 Contact email: phm@msu.edu\n
 for more info visit the web at:\n 
 http://phmtox.msu.edu/events/pdf/SHAH%20Y--Flyer.pdf\n
LOCATION:110 Radiology Bldg Auditorium
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