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DTSTAMP:20120625T160000Z
UID:1340113342471@events.msu.edu
CATEGORIES:Conferences / Seminars / Lectures
DTSTART:20120625T160000Z
DTEND:20120625T170000Z
SUMMARY:Candidate for Chair of Pharmacology & Toxicology
DESCRIPTION:
 RONALD MAGNESS - Professor, Obstetrics & Gynecology\n
 University 
 of Wisconsin, Madison, WI\n
 \n
 ENDOTHELIAL MECHANISMS CONTROLLING BLOOD FLOW 
 AND\n
 VASCULAR ADAPTATIONS DURING GESTATION 
 MAY UNDERLIE THE DEVELOPMENTAL ORIGINS OF ADULT 
 ONSET DISEASE\n
 \n
 Host: Cheryl Sisk\n
 \n
 Normal 
 gestation is characterized by dramatic increases 
 of cardiac output (total systemic flow) 
 in association with substantial redistribution 
 of utero-placental blood flow (UBF) in order 
 to support adequate fetal growth and development. 
 The specific mechanisms controlling 
 perfusion at the maternal-fetal interface include 
 vasodilatation, vascular remodeling, and 
 angiogenesis. Defining these specific mechanisms 
 is significant because reduced uterine 
 and placental blood flows are seen in all models 
 of intrauterine growth restriction (IUGR), 
 resulting in both increased fetal morbidity 
 and long-term Developmental Origins of Adult 
 Onset Diseases, including higher cardiac disease, 
 hypertension, type II diabetes and cancers. 
 I will present evidence that regulation 
 of coordinated rises in cardiac output (total 
 systemic flow) and redistribution of blood flows 
 to the uterine maternal-fetal interface 
 are modulated by convergent and interactive endothelial 
 eNOS/NO associated local signaling 
 mechanisms, including angiogenic factors, estrogen, 
 and shear stresses, all of which are 
 important to fetal development. Loss of this 
 maintenance of normal fetal developmental growth 
 patterns, as seen in IUGR, underlies in part 
 the long term health consequences as we age.\n\n
 Price: free\n
 Sponsor: Administration\n
 Sponsor's Homepage: http://events.msu.edu/deptpharmacology/\n
 Contact name: Diane Hummel\n
 Contact phone: 884-3553\n
 Contact email: phm@msu.edu\n
 for more info visit the web at:\n 
 http://phmtox.msu.edu/events/pdf/Magness--Seminar%20Flyer.pdf\n
LOCATION:B448 Life Sciences
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