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DTSTAMP:20150226T150000Z
UID:1424113649066@events.msu.edu
CATEGORIES:Conferences / Seminars / Lectures
DTSTART:20150226T150000Z
DTEND:20150227T045900Z
SUMMARY:Physiology Seminar
DESCRIPTION:
 Dept. of Physiology Research Seminar: Dr. Michael 
 Gatza - "An integrated genomics approach 
 to identify drivers of oncogenesis and oncogenic 
 signaling in human breast cancer"\n
 \n
 Elucidating 
 the molecular drivers of human breast 
 cancers requires a strategy capable of integrating 
 multiple forms of genomic data and an 
 ability to interpret the functional consequences 
 of a given genetic aberration. We developed 
 an integrated genomic strategy based on the 
 use of gene expression signatures of oncogenic 
 pathway activity as a framework to analyze 
 genomic data from human tumors in combination 
 with data from a genome-wide RNAi screen. 
 Using this strategy, we identified specific DNA 
 amplifications, and importantly, essential 
 genes within these amplicons representing key 
 genetic drivers, including known and novel 
 regulators of oncogenesis and oncogenic signaling. 
 Our results demonstrate that this general 
 strategy has the potential to identify drivers 
 of oncogenesis and oncogenic signaling pathways 
 which may represent putative therapeutic 
 targets within amplicons through an integrated 
 use of genetic, genomic, and genome-wide 
 RNAi data.\n\n
 Price: free\n
 Sponsor: Dept. of Physiology\n
 Sponsor's Homepage: http://www.psl.msu.edu/\n
 Contact name: Chris Shaltry\n
 Contact phone: 884-5034\n
 Contact email: shaltryc@cns.msu.edu\n
 for more info visit the web at:\n 
 http://www.psl.msu.edu/\n
LOCATION:1425 Biomedical and Physical Sciences Bldg
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