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DTSTAMP:20150219T150000Z
UID:1424113727864@events.msu.edu
CATEGORIES:Conferences / Seminars / Lectures
DTSTART:20150219T150000Z
DTEND:20150220T045900Z
SUMMARY:Physiology Seminar
DESCRIPTION:
 Dept. of Physiology Research Seminar: Dr. Joseph 
 Barbi - "Neuritin: An unexpected immune modulator 
 and regulator of regulators"\n
 \n
 Regulatory 
 T cells (Tregs) are major enforcers of 
 immune homeostasis that prevent excessive or 
 self-directed responses. These cells in the cancer 
 setting, however, can hinder both the anti-tumor 
 immune response and the effectiveness 
 of anti-cancer vaccines. Therefore understanding 
 the factors important for Treg maintenance 
 and function is relevant to a wide range 
 of diseases. We found that neuritin, a gpi-anchored 
 molecule known for its role in the nervous 
 system, was highly expressed by induced 
 and natural Tregs. Neuritin expression was important 
 for the maintenance of the Treg phenotype 
 and the function of these cells in vivo. 
 In a mouse model of colitis, neuritin ablation 
 undermined Treg-mediated immune control evidenced 
 by poor retention of Foxp3 expression 
 by Tregs and elevated levels of proinflammatory 
 cytokines. Additionally, the growth of implanted 
 tumors was strongly impeded in the absence 
 of neuritin. In all these findings characterize 
 neuritin as a Treg-derived factor important 
 for immune tolerance and a potential 
 therapeutic opportunity to modulate the Treg 
 pool. Ongoing studies are exploring the mechanisms 
 responsible for neuritin-mediated immune 
 regulation and elucidating the molecule events 
 and cells involved.\n\n
 Price: free\n
 Sponsor: Dept. of Physiology\n
 Sponsor's Homepage: http://www.psl.msu.edu/\n
 Contact name: Chris Shaltry\n
 Contact phone: 884-5034\n
 Contact email: shaltryc@cns.msu.edu\n
 for more info visit the web at:\n 
 http://www.psl.msu.edu/\n
LOCATION:1425 Biomedical and Physical Sciences Bldg
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