BEGIN:VCALENDAR
VERSION:2.0
METHOD:PUBLISH
PRODID:-//Virginia Tech//VT Calendar//EN
BEGIN:VEVENT
DTSTAMP:20150305T150000Z
UID:1424113795795@events.msu.edu
CATEGORIES:Conferences / Seminars / Lectures
DTSTART:20150305T150000Z
DTEND:20150306T045900Z
SUMMARY:Physiology Seminar
DESCRIPTION:
 Dept. of Physiology Research Seminar: Dr. Marc 
 Mendillo - "Regulation and impact of HSF1 in 
 highly malignant human cancers"\n
 \n
 The heat-shock 
 response is an ancient and powerful adaptive 
 mechanism that enables organisms to survive 
 diverse proteotoxic stressors. In mouse 
 models, HSF1 is co-opted by tumor cells to promote 
 their survival, to the detriment of their 
 hosts. The common assumption was that these 
 effects are mediated through regulation of 
 chaperone protein expression. Integrating cell 
 biological, genomic and bioinformatic methods, 
 we reveal a direct and pervasive role for 
 HSF1 in many facets of tumorigenesis, extending 
 far beyond protein folding and stress responses 
 to include cell cycle, apoptosis, energy 
 metabolism and other proliferation-associated 
 processes. We used these data to define an 
 HSF1-regulated expression signature in malignancy 
 and analyzed previously published expression 
 data sets from collections of breast, 
 colon and lung patient tumors with outcome associations. 
 We find that high expression of this 
 HSF1 cancer signature correlates strongly 
 with metastasis and death. Thus, HSF1 engages 
 a regulatory program in the highly malignant 
 state that is distinct from the classic heat-shock 
 response. In a second series of experiments, 
 we used an integrated chemical, genetic 
 and genomic approach and revealed a fundamental 
 link between anabolic cellular processes: 
 protein production, HSF1 activity and energy 
 metabolism. Importantly, exploiting this link 
 with translation initiation inhibitors such 
 as rocaglates selectively impaired the proliferation 
 of neoplastic cells. Moreover, this 
 tight coordination of protein synthesis and 
 HSF1 activation suggests a unifying principle 
 that explains the HSF1 activation we previously 
 observed in the extraordinarily wide range 
 of human cancers.\n\n
 Price: free\n
 Sponsor: Dept. of Physiology\n
 Sponsor's Homepage: http://www.psl.msu.edu/\n
 Contact name: Chris Shaltry\n
 Contact phone: 884-5034\n
 Contact email: shaltryc@cns.msu.edu\n
 for more info visit the web at:\n 
 http://www.psl.msu.edu/\n
LOCATION:1425 Biomedical and Physical Sciences Bldg
END:VEVENT
END:VCALENDAR