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PRODID:-//Virginia Tech//VT Calendar//EN
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DTSTAMP:20150326T150000Z
UID:1424448884442@events.msu.edu
CATEGORIES:Conferences / Seminars / Lectures
DTSTART:20150326T150000Z
DTEND:20150327T045900Z
SUMMARY:Physiology Seminar
DESCRIPTION:
 Dept. of Physiology Research Seminar: Dr. Hariharan 
 Subramanian - "Role of Adapter Molecules 
 in Regulating Mast Cell Functions"\n
 \n
 Allergic 
 diseases are among the major causes of illness 
 and disability for all ages. These diseases 
 are caused by an overzealous immune response 
 to allergens in which immunoglobulin E (IgE) 
 and mast cells play critical roles. Thus, 
 aggregation of high affinity IgE receptor (FceRI) 
 on mast cells by allergen results in rapid 
 release of mast cells granules (degranulation) 
 and the generation of inflammatory mediators 
 which are responsible for the manifestations 
 of allergic diseases. Previous reports 
 have demonstrated that activation of G protein 
 coupled receptors (GPCRs) exacerbated FceRI-induced 
 responses in mast cells. Agonist-induced 
 phosphorylation of GPCRs by GPCR kinases 
 (GRKs) leads to the recruitment of a family 
 of adapter molecules called β-arrestins, 
 which promotes desensitization and internalization 
 of the receptor. My research focuses 
 on the role of these adapter molecules in regulating 
 GPCR-induced mast cell functions. In 
 addition, I have made the novel observation that 
 GRKs and β-arrestins modulate FceRI-induced 
 signaling in mast cells. Thus, understanding 
 these previously unappreciated mechanisms 
 of mast cell activation may lead to the 
 development of novel approaches for the treatment 
 of asthma and allergic diseases.\n\n
 Price: free\n
 Sponsor: Dept. of Physiology\n
 Sponsor's Homepage: http://www.psl.msu.edu/\n
 Contact name: Chris Shaltry\n
 Contact phone: 884-5034\n
 Contact email: shaltryc@cns.msu.edu\n
 for more info visit the web at:\n 
 http://www.psl.msu.edu/\n
LOCATION:1425 Biomedical and Physical Sciences Bldg
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