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DTSTAMP:20150312T150000Z
UID:1425497919922@events.msu.edu
CATEGORIES:Conferences / Seminars / Lectures
DTSTART:20150312T150000Z
DTEND:20150313T045900Z
SUMMARY:Physiology Seminar
DESCRIPTION:
 Research Seminar: "In vivo imaging revealed early 
 microglial responses and coagulation activity 
 in neuroinflammatory disease" Dr. Dr. Davlos 
 Dimitrios,\n
 Staff Research Scientist, Gladstone 
 Institutes\n
 \n
 Microglia are the brain's 
 resident immune cells, but their importance 
 for normal brain function was underappreciated 
 for many decades. By imaging their behavior 
 in the intact living brain using two-photon 
 microscopy, we demonstrated for the first time 
 that they constantly survey the physiological 
 brain by extending and retracting their 
 fine processes. We also showed that they rapidly 
 respond to focal brain injury, and identified 
 purinergic signaling as a key pathway mediating 
 these unexpectedly rapid responses. In 
 recent years we studied how microglia become 
 activated during the course of neuroinflammatory 
 disease, and found a molecular link between 
 blood-brain barrier (BBB) disruption and 
 new lesion formation in an animal model for 
 multiple sclerosis. Ongoing research is focused 
 at characterizing the activation profile of 
 microglia and macrophages after ischemic injury 
 in vivo. Future research interests include 
 studying the cellular and molecular mechanisms 
 through which microglia interact with the 
 BBB and potentially regulate its disruption 
 and its restoration at different stages of neurological 
 disease, as well as deciphering the 
 effects of microglial activation on neuronal 
 plasticity and function in physiology and 
 in disease. The seminar with also highlight the 
 technologies and methods that make in vivo 
 imaging studies of ongoing biological processes 
 in the brain and spinal cord of mice possible.\n\n
 Price: free\n
 Sponsor: Dept. of Physiology\n
 Sponsor's Homepage: http://www.psl.msu.edu/\n
 Contact name: Chris Shaltry\n
 Contact phone: 884-5034\n
 Contact email: shaltryc@cns.msu.edu\n
 for more info visit the web at:\n 
 http://www.psl.msu.edu/\n
LOCATION:1425 Biomedical and Physical Sciences Bldg
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