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DTSTAMP:20240121T180000Z
UID:1704912550275@events.msu.edu
CATEGORIES:Conferences / Seminars / Lectures
DTSTART:20240121T180000Z
DTEND:20240121T190000Z
SUMMARY:Emery Brown - Deciphering the Dynamics of the Unconscious Brain under General Anesthesia
DESCRIPTION:
 "General anesthesia is a drug-induced, reversible 
 condition comprised of five behavioral 
 states: unconsciousness, amnesia (loss of 
 memory), antinociception (loss of pain sensation), 
 akinesia (immobility), and hemodynamic 
 stability with control of the stress response. 
 Our work shows that a primary mechanism through 
 which anesthetics create these altered states 
 of arousal is by initiating and maintaining 
 highly structured oscillations. These oscillations 
 impair communication among brain regions. 
 We illustrate this effect by presenting 
 findings from our human and non-human primate 
 studies using high-density EEG recordings 
 and intracranial recordings. These studies have 
 allowed us to give a detailed characterization 
 of the neurophysiology of loss and recovery 
 of consciousness due to propofol, and more 
 recently ketamine. We show how these dynamics 
 change systematically with different anesthetic 
 classes and with age. As a consequence, 
 we have developed a principled, neuroscience-based 
 paradigm for using the EEG to monitor 
 the brain states of patients receiving general 
 anesthesia. We demonstrate that the state 
 of general anesthesia can be rapidly reversed 
 by activating specific brain circuits. Finally, 
 we demonstrate that the state of general 
 anesthesia can be controlled using closed-loop 
 feedback control systems.  The success of our 
 research has depended critically on tight 
 coupling of experiments, signal processing research 
 and mathematical modeling."\n
 \n
 Bio\n
 Emery 
 N. Brown is the Edward Hood Taplin Professor 
 of Medical Engineering and Computational 
 Neuroscience at the Massachusetts Institute 
 of Technology (MIT); the Warren M. Zapol 
 Professor of Anesthesia at Harvard Medical School; 
 and an anesthesiologist at Massachusetts 
 General Hospital (MGH). \n
 \n
 He received his 
 bachelor's degree in Applied Mathematics (magna 
 cum laude) from Harvard College, his master's 
 degree and PhD in statistics from Harvard 
 University and his doctor of medicine degree 
 (magna cum laude) from Harvard Medical School. 
 Brown completed his internship in internal 
 medicine at the Brigham and Women's Hospital 
 and his anesthesiology residency at MGH. \n
 \n
 Brown is an anesthesiologist-statistician whose 
 research is defining the neuroscience of 
 how anesthetics produce the states of general 
 anesthesia. He also develops statistical methods 
 for neuroscience data analysis.\n
 \n
 Brown 
 is a fellow of the IEEE, the American Association 
 for the Advancement of Science, the American 
 Academy of Arts Sciences, and the National 
 Academy of Inventors. He is a member of 
 the National Academy of Medicine, National Academy 
 of Sciences, the National Academy of Engineering 
 and the American Philosophical Society. 
 \n
 \n
 Brown has received an NIH Director's 
 Pioneer Award, an NIH Director's Transformative 
 Research Award, the Sacks Prize from the 
 National Institute of Statistical Science, a 
 Guggenheim Fellowship in Applied Mathematics, 
 the American Society of Anesthesiologists Excellence 
 in Research Award, the Dickson Prize 
 in Science, the Swartz Prize for Theoretical 
 and Computational Neuroscience, the Pierre Galletti 
 Award, the Gruber Prize in Neuroscience, 
 and  Doctors of Science Honoris Causa from 
 the University of Southern California and SUNY 
 Downstate.\n
 \n\n
 Price: free\n
 Sponsor: public\n
 Contact name: Bob Patterer\n
 Contact email: events@frib.msu.edu\n
 for more info visit the web at:\n 
 https://frib.msu.edu/gateway/events/talk-emery_brown.html\n
LOCATION:Virtual
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