MSU Events Calendar |
 12:00pm to 1:00pm |
RALPH LYDIC, PhD Professor Department of Anesthesiology U of M Medical School Ann Arbor
(Conferences / Seminars / Lectures) In 2000 the editors of the New England Journal of Medicine listed the development of safe and reliable anesthesia as one of the major medical advances in the past thousand years. Continuing progress in basic and clinical pharmacology has contributed to efforts to understand the cellular and molecular mechanisms of anesthesia. For no molecule, however, do we understand the mechanisms that cause the loss of wakefulness and the onset of an anesthetic state. It has become clear that molecular actions at the lipid bilayer and/or on cell surface proteins can not explain the generation of anesthetic states. An alternative, heuristic model is that brain regions which evolved to generate naturally occurring states of sleep and wakefulness are preferentially involved in generating the physiological and behavioral traits that comprise states of anesthesia. This talk will highlight recent neurochemical evidence showing that brain regions and neurotransmitters know to regulate sleep and wakefulness are significantly altered by anesthetics. more information...
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353-9616
