The Role of Hypoxia in Gastrointestinal Homeostasis
(Conferences / Seminars / Lectures)
YATRIK SHAH, PhD more information...
Molecular & Integrative Physiology
University of Michigan
Ann Arbor, MI
HOST: Bryan Copple
Two billion years of evolution in an oxygen environment has determined that oxygen occupies a
central feature of our biology. Cellular oxygen is an important systemic signal that modulates
metabolic activities and disease in the liver and intestine. Low cellular oxygen also referred to as
hypoxia is observed in several gastrointestinal diseases such as non-alcoholic and alcoholic fatty
liver disease, inflammatory bowel disease and liver and colon cancers. Regulation of hypoxiamediated
genes is dependent on the nuclear transcription factor, hypoxia inducible factor (HIF).
HIF signaling is critical in the adaptive response to low oxygen levels by activating genes involved
in metabolism, angiogenesis, cell survival and iron metabolism. Using the latest in mouse
transgenic technology we have developed novel animal models to study accurately the role of
oxygen sensitive transcription factors in the liver and intestine. The major goal of our research
program is to determine the molecular mechanisms by which oxygen sensing transcription factors
regulate gastrointestinal homeostasis, inflammation and cancer.