Candidate for Chair of Pharmacology & Toxicology
(Conferences / Seminars / Lectures)
RONALD MAGNESS - Professor, Obstetrics & Gynecology more information...
University of Wisconsin, Madison, WI
ENDOTHELIAL MECHANISMS CONTROLLING BLOOD FLOW AND
VASCULAR ADAPTATIONS DURING GESTATION MAY UNDERLIE THE DEVELOPMENTAL ORIGINS OF ADULT ONSET DISEASE
Host: Cheryl Sisk
Normal gestation is characterized by dramatic increases of cardiac output (total systemic flow) in association with substantial redistribution of utero-placental blood flow (UBF) in order to support adequate fetal growth and development. The specific mechanisms controlling perfusion at the maternal-fetal interface include vasodilatation, vascular remodeling, and angiogenesis. Defining these specific mechanisms is significant because reduced uterine and placental blood flows are seen in all models of intrauterine growth restriction (IUGR), resulting in both increased fetal morbidity and long-term Developmental Origins of Adult Onset Diseases, including higher cardiac disease, hypertension, type II diabetes and cancers. I will present evidence that regulation of coordinated rises in cardiac output (total systemic flow) and redistribution of blood flows to the uterine maternal-fetal interface are modulated by convergent and interactive endothelial eNOS/NO associated local signaling mechanisms, including angiogenic factors, estrogen, and shear stresses, all of which are important to fetal development. Loss of this maintenance of normal fetal developmental growth patterns, as seen in IUGR, underlies in part the long term health consequences as we age.