Monday, February 16, 2015
Corey R. Hopkins, Ph.D.
(Conferences / Seminars / Lectures)
Research Assistant Professor more information...
Vanderbilt Center for Neuroscience Drug Discovery
Discovery and Development of Small Molecules As Potential First-In-Class Therapeutics
HOST: Richard Neubig, M.D., Ph. D.
The seminar will highlight work from my laboratory in the discovery and development of novel tool compounds for a variety of therapeutic indications. Work covered will include positive allosteric modulators (PAMs) of the metabotropic glutamate receptor 4 for Parkinson's disease, novel BMP inhibitors/potentiators for Tylenol overdose and fibrodysplasia ossificans progressiva (FOP) and inhibitors of TRPC4/5 for the protection of the kidney filter. Compounds were identified by traditional high-throughput screening as well as from a high-content in vivo zebrafish screen and optimized utilizing iterative medicinal chemistry, in vitro and in vivo PK, and in vivo animal models at Vanderbilt University.