Dept. of Physiology Research Seminar: Dr. Michael Gatza - "An integrated genomics approach to identify drivers of oncogenesis and oncogenic signaling in human breast cancer"

Elucidating the molecular drivers of human breast cancers requires a strategy capable of integrating multiple forms of genomic data and an ability to interpret the functional consequences of a given genetic aberration. We developed an integrated genomic strategy based on the use of gene expression signatures of oncogenic pathway activity as a framework to analyze genomic data from human tumors in combination with data from a genome-wide RNAi screen. Using this strategy, we identified specific DNA amplifications, and importantly, essential genes within these amplicons representing key genetic drivers, including known and novel regulators of oncogenesis and oncogenic signaling. Our results demonstrate that this general strategy has the potential to identify drivers of oncogenesis and oncogenic signaling pathways which may represent putative therapeutic targets within amplicons through an integrated use of genetic, genomic, and genome-wide RNAi data.

Location:	1425 Biomedical and Physical Sciences Bldg [map]
Price:	free
Sponsor:	Dept. of Physiology
Contact:	Chris Shaltry shaltryc@cns.msu.edu 884-5034
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